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Article

Mutations within the nuclear localization signal of the porcine reproductive and respiratory syndrome virus nucleocapsid protein attenuate virus replication.

Virology - 1 Mar 2006

Lee Changhee, Hodgins Douglas, Calvert Jay G, Welch Siao-Kun W, Jolie Rika, Yoo Dongwan

Abstract excerpt

Porcine reproductive and respiratory syndrome virus (PRRSV) is an RNA virus replicating in the cytoplasm, but the nucleocapsid (N) protein is specifically localized to the nucleus and nucleolus in virus-infected cells. A 'pat7' motif of 41-PGKK(N/S)KK has previously been identified in the N protein as the functional nuclear localization signal (NLS); however, the biological consequences of N protein nuclear...

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Identifiers

PMID: 16330065
DOI: 10.1016/j.virol.2005.11.005
PMCID: PMC7172752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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