Article
Human genetic evidence that OX40 is implicated in myocardial infarction.
Biochemical and biophysical research communications - 20 Jan 2006
Ria Massimiliano, Eriksson Per, Boquist Susanna, Ericsson Carl-Göran, Hamsten Anders, Lagercrantz Jacob
Abstract excerpt
We recently showed that genetic variants in OX40L are associated with myocardial infarction (MI) and severity of coronary artery disease in human. A number of studies also suggest a possible role for OX40 (the OX40L receptor) as a factor contributing to atherosclerosis. In the present study, the OX40 gene was screened for variants associated with precocious MI, using individuals with MI before the age of 60 and...
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