Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of the truncating splice site mutation in BTNL2 with multiple sclerosis is secondary to HLA-DRB1*15.

Human molecular genetics - 1 Jan 2006

Traherne James A, Barcellos Lisa F, Sawcer Stephen J, Compston Alastair, Ramsay Patricia P, Hauser Stephen L, Oksenberg Jorge R, Trowsdale John

Abstract excerpt

The major histocompatibility complex human leukocyte antigen (HLA)-DRB1*15 (DR2) haplotype is strongly associated with risk of multiple sclerosis (MS). The primary susceptibility has been localized to only approximately 200 kb encompassing the HLA-DR and -DQ loci. Further dissection of disease association with this region is demanding because of the high levels of linkage disequilibrium (LD). Recently, evidence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black or African American
Share to Butyrophilins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Components

Share to HLA-DR Antigens

Share to HLA-DRB1 Chains

Share to Multiple Sclerosis

Share to RNA Splice Sites

Share to United Kingdom

Source

Identifiers

PMID: 16321988
DOI: 10.1093/hmg/ddi436

Genes

BTNL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of the truncating splice site mutation in BTNL2 with multiple sclerosis is secondary to HLA-DRB1*15.PMID 16321988Read ↗

Sarcoidosis is associated with a truncating splice site mutation in BTNL2.Semantic proximity Read ↗

Analysis of the BTNL2 truncating splice site mutation in tuberculosis, leprosy and Crohn's disease.Semantic proximity Read ↗

Analysis of BTNL2 genetic polymorphisms in British and Dutch patients with sarcoidosis.Semantic proximity Read ↗

Association of the BTNL2 rs2076530 single nucleotide polymorphism with Graves' disease appears to be secondary to DRB1 exon 2 position beta74.Semantic proximity Read ↗

The BTNL2 gene and sarcoidosis susceptibility in African Americans and Whites.Semantic proximity Read ↗

Allelic variation in BTNL2 and susceptibility to tuberculosis in a South African population.Semantic proximity Read ↗

Homozygous variant rs2076530 of BTNL2 and familial sarcoidosis.Semantic proximity Read ↗

Genetic characterization and susceptibility for sarcoidosis in Japanese patients: risk factors of BTNL2 gene polymorphisms and HLA class II alleles.Semantic proximity Read ↗

A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.Semantic proximity Read ↗

Analysis of the association between BTNL2 polymorphism and tuberculosis in Chinese Han population.Semantic proximity Read ↗

Is there a genetic predisposition for Turkish patients with sarcoidosis in the 329-bp region containing the BTNL2 rs2076530 polymorphism?Semantic proximity Read ↗

BTNL2 gene polymorphism and sarcoidosis susceptibility: a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.