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Article

CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B' helix defines substrate preferences of sterol 14alpha-demethylase.

The Journal of biological chemistry - 10 Feb 2006

Lepesheva Galina I, Zaitseva Natalia G, Nes W David, Zhou Wenxu, Arase Miharu, Liu Jialin, Hill George C, Waterman Michael R

Abstract excerpt

A potential drug target for treatment of Chagas disease, sterol 14alpha-demethylase from Trypanosoma cruzi (TCCYP51), was found to be catalytically closely related to animal/fungi-like CYP51. Contrary to the ortholog from Trypanosoma brucei (TB), which like plant CYP51 requires C4-monomethylated sterol substrates, TCCYP51 prefers C4-dimethylsterols. Sixty-six CYP51 sequences are known from bacteria to human,...

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Identifiers

PMID: 16321980
DOI: 10.1074/jbc.M510317200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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