Article
Abnormalities in neural crest cell migration in laminin alpha5 mutant mice.
Developmental biology - 1 Jan 2006
Coles Edward G, Gammill Laura S, Miner Jeffrey H, Bronner-Fraser Marianne
Abstract excerpt
Although numerous in vitro experiments suggest that extracellular matrix molecules like laminin can influence neural crest migration, little is known about their function in the embryo. Here, we show that laminin alpha5, a gene up-regulated during neural crest induction, is localized in regions of newly formed cranial and trunk neural folds and adjacent neural crest migratory pathways in a manner largely...
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