Disruption of Sept6, a fusion partner gene of MLL, does not affect ontogeny, leukemogenesis induced by MLL-SEPT6, or phenotype induced by the loss of Sept4.

doi:10.1128/MCB.25.24.10965-10978.2005

Article

Disruption of Sept6, a fusion partner gene of MLL, does not affect ontogeny, leukemogenesis induced by MLL-SEPT6, or phenotype induced by the loss of Sept4.

Molecular and cellular biology - 1 Dec 2005

Ono Ryoichi, Ihara Masafumi, Nakajima Hideaki, Ozaki Katsutoshi, Kataoka-Fujiwara Yuki, Taki Tomohiko, Nagata Koh-Ichi, Inagaki Masaki, Yoshida Nobuaki, Kitamura Toshio, Hayashi Yasuhide, Kinoshita Makoto, Nosaka Tetsuya

Abstract excerpt

Septins are evolutionarily conserved GTP-binding proteins that can heteropolymerize into filaments. Recent studies have revealed that septins are involved in not only diverse normal cellular processes but also the pathogenesis of various diseases, including cancer. SEPT6 is ubiquitously expressed in tissues and one of the fusion partner genes of MLL in the 11q23 translocations implicated in acute leukemia....

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Disruption of Sept6, a fusion partner gene of MLL, does not affect ontogeny, leukemogenesis induced by MLL-SEPT6, or phenotype induced by the loss of Sept4.

Abstract excerpt

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