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Article

Role of SPI-1 in the interactions of Salmonella Typhimurium with porcine macrophages.

Veterinary microbiology - 10 Mar 2006

Boyen F, Pasmans F, Donné E, Van Immerseel F, Adriaensen C, Hernalsteens J-P, Ducatelle R, Haesebrouck F

Abstract excerpt

Salmonella Pathogenicity Island 1 (SPI-1) genes are indispensable for virulence of Salmonella Typhimurium in mice after oral challenge. These genes mediate invasion in intestinal epithelial cells and induce cell death in murine macrophages. The role of SPI-1 in the pathogenesis of Salmonella Typhimurium infections in food producing animals is not known. It was the aim of the present study to characterize the...

Topics

Animals
Bacterial Proteins
Cytotoxicity Tests, Immunologic
DNA Primers
Interleukin-8
Macrophages, Alveolar
Membrane Proteins
Microfilament Proteins
Mutation
Phagosomes
Reactive Oxygen Species

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Salmonella Infections, Animal

Salmonella typhimurium

Swine

Time Factors

Trans-Activators

Source

Identifiers

PMID: 16310983
DOI: 10.1016/j.vetmic.2005.10.018

Genes

PAM

Provenance

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