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Article

Sleep restriction by forced activity reduces hippocampal cell proliferation.

Brain research - 14 Dec 2005

Roman Viktor, Van der Borght Karin, Leemburg Susan A, Van der Zee Eddy A, Meerlo Peter

Abstract excerpt

Mounting evidence suggests that sleep loss negatively affects learning and memory processes through disruption of hippocampal function. In the present study, we examined whether sleep loss alters the generation, differentiation, and survival of new cells in the dentate gyrus. Rats were sleep restricted by keeping them awake in slowly rotating drums for 1 day or repeatedly for 20 h/day over a period of 8 days. In...

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PMID: 16309630
DOI: 10.1016/j.brainres.2005.10.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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