Article
Phenotypic changes in mitochondrial membrane potential (Delta psi(m)) during valinomycin-induced depolarisation and apoptosis.
Cellular oncology : the official journal of the International Society for Cellular Oncology - 1 Jan 2005
Morrison M L, Williamson K, Arthur K, Price G J, Hamilton P W, Maxwell P
Abstract excerpt
A large body of evidence has implicated mitochondria in control of cell death, where key apoptotic mechanisms involve change in mitochondrial membrane permeability and depolarisation of mitochondrial membrane potential (Delta psi(m)). Assessment of Delta psi(m) is traditionally conducted using the lipophilic cation JC-1 on the flow cytometer or by fluorescent microscopy. Here we assess JC-1 aggregation using the...
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