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Article

The long terminal repeat is a determinant of cell tropism of maedi-visna virus

1 Aug 2000

Abstract excerpt

Maedi-visna virus (MVV) is a lentivirus of sheep, mainly affecting the lungs and the central nervous system. Long terminal repeat (LTR) sequence variability is common in tissue culture-derived isolates of MVV as well as those of other lentiviruses. The role of this sequence variation in MVV replication has not been explored. PCR amplification of the LTRs of an MVV isolate revealed two product sizes, the larger...

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PMID: 10900026
DOI: 10.1099/0022-1317-81-8-1901

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