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Article

Fuchs corneal dystrophy: aberrant collagen distribution in an L450W mutant of the COL8A2 gene.

Investigative ophthalmology & visual science - 1 Dec 2005

Gottsch John D, Zhang Cheng, Sundin Olof H, Bell W Robert, Stark Walter J, Green W Richard

Abstract excerpt

PURPOSE: To characterize histologically Descemet's membrane in an early-onset Fuchs corneal dystrophy (FCD) COL8A2 mutant and compare these findings with corneas from late-onset FCD and normal corneas. METHODS: A corneal explant from a patient with the L450W COL8A2 mutation and others with late-onset disease were studied with antibodies to collagens IV, VIIIA1, VIIIA2, fibronectin, and laminin. Transmission...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Fluorescent Antibody Technique, Indirect

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Source

Identifiers

PMID: 16303941
DOI: 10.1167/iovs.05-0497

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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