Article
Ectophosphorylation of CD36 regulates cytoadherence of Plasmodium falciparum to microvascular endothelium under flow conditions.
Infection and immunity - 1 Dec 2005
Ho May, Hoang Holly L, Lee Kristine M, Liu Naili, MacRae Tara, Montes Laura, Flatt Christine L, Yipp Bryan G, Berger Bradley J, Looareesuwan Sorrnchai, Robbins Stephen M
Abstract excerpt
The adhesion of Plasmodium falciparum-infected erythrocytes (IRBCs) to human dermal microvascular endothelial cells (HDMECs) under flow conditions is regulated by a Src family kinase- and alkaline phosphatase (AP)-dependent mechanism. In this study, we showed that the target of the phosphatase activity is the ectodomain of CD36 at threonine-92 (Thr92). Mouse fibroblasts (NIH 3T3 cells) transfected with wild-type...
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