Article
A photoactivable probe for calcium binding proteins.
Chemistry & biology - 1 Nov 2005
Israelson Adrian, Arzoine Laetitia, Abu-hamad Salah, Khodorkovsky Vladimir, Shoshan-Barmatz Varda
Abstract excerpt
Ca2+ as a signaling molecule carries information pivotal to cell life and death via its reversible interaction with a specific site in a protein. Although numerous Ca2+-dependent activities are known, the proteins responsible for some of these activities remain unidentified. We synthesized and characterized a photoreactive reagent, azido ruthenium (AzRu), which interacts specifically with Ca2+ binding proteins...
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