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Article

Human SOD1 before harboring the catalytic metal: solution structure of copper-depleted, disulfide-reduced form.

The Journal of biological chemistry - 27 Jan 2006

Banci Lucia, Bertini Ivano, Cantini Francesca, D'Amelio Nicola, Gaggelli Elena

Abstract excerpt

SOD1 has to undergo several post-translational modifications before reaching its mature form. The protein requires insertion of zinc and copper atoms, followed by the formation of a conserved S-S bond between Cys-57 and Cys-146 (human numbering), which makes the protein fully active. In this report an NMR structural investigation of the reduced SH-SH form of thermostable E,Zn-as-SOD1 (E is empty; as is C6A,...

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Share to Catalysis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16291742
DOI: 10.1074/jbc.M506497200

Genes

SOD1
CCS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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