Article
Developmental abnormalities in the Nuc1 rat retina: a spontaneous mutation that affects neuronal and vascular remodeling and retinal function.
Neuroscience - 1 Jan 2006
Gehlbach P, Hose S, Lei B, Zhang C, Cano M, Arora M, Neal R, Barnstable C, Goldberg M F, Zigler J Samuel, Sinha D
Abstract excerpt
The retina serves as an excellent model in which to study vertebrate CNS development. We have discovered a spontaneous mutation in the Sprague-Dawley rat that results in a novel and unusual ocular phenotype, including retinal abnormalities, that we have named Nuc1. We have previously shown that the Nuc1 mutation appears to suppress programmed cell death in the developing retina. Here we report that maturation of...
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