Article
Interleukin-6 involvement in brain arteriovenous malformations.
Annals of neurology - 1 Jan 2006
Chen Yongmei, Pawlikowska Ludmila, Yao Jianhua S, Shen Fanxia, Zhai Wenwu, Achrol Achal S, Lawton Michael T, Kwok Pui-Yan, Yang Guo-Yuan, Young William L
Abstract excerpt
We recently reported that the GG genotype of the interleukin-6 (IL-6)-174G>C promoter polymorphism is associated with clinical presentation of intracranial hemorrhage in brain arteriovenous malformation (AVM) patients. In this study, we investigated whether tissue IL-6 expression was associated with IL-6-174G>C genotype, and whether IL-6 was linked to downstream targets involved in angiogenesis and vascular...
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