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DNA Replication Licensing Factors and Aurora Kinases are Linked to Aneuploidy and Clinical Outcome in Epithelial Ovarian Carcinoma

15 Oct 2007

Abstract excerpt

PURPOSE: DNA replication licensing factors and Aurora kinases play critical roles in maintaining genomic integrity. We used multiparameter analyses of these cell cycle regulatory proteins to investigate their role in the progression of epithelial ovarian carcinoma (EOC). EXPERIMENTAL DESIGN: In a cohort of 143 patients, we linked the protein expression profiles of the proliferation marker Ki67, the replication...

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PMID: 17947481
DOI: 10.1158/1078-0432.ccr-07-0671

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