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Article

Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis.

The EMBO journal - 16 Nov 2005

Coultas Leigh, Bouillet Philippe, Loveland Kate L, Meachem Sarah, Perlman Harris, Adams Jerry M, Strasser Andreas

Abstract excerpt

The BH3-only proteins of the Bcl-2 family initiate apoptosis through the activation of Bax-like relatives. Loss of individual BH3-only proteins can lead either to no phenotype, as in mice lacking Bik, or to marked cell excess, as in the hematopoietic compartment of animals lacking Bim. To investigate whether functional redundancy with Bim might obscure a significant role for Bik, we generated mice lacking both...

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Source

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Identifiers

PMID: 16270031
DOI: 10.1038/sj.emboj.7600857
PMCID: PMC1283956

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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