Article
Involvement of deacylation in activation of substrate hydrolysis by Drosophila acetylcholinesterase.
The Journal of biological chemistry - 25 May 2001
Brochier L, Pontié Y, Willson M, Estrada-Mondaca S, Czaplicki J, Klaébé A, Fournier D
Abstract excerpt
Insect acetylcholinesterase (AChE), an enzyme whose catalytic site is located at the bottom of a gorge-like structure, hydrolyzes its substrate over a wide range of concentrations (from 2 microm to 300 mm). AChE is activated at low substrate concentrations and inhibited at high substrate concentrations. Several rival kinetic models have been developed to try to describe and explain this behavior. One of these...
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