Familial Alzheimer's mutation: mRNA secondary structure revisited.

doi:10.1016/0197-4580(92)90120-m

Back to search

Article

Familial Alzheimer's mutation: mRNA secondary structure revisited.

Neurobiology of aging - 1 Jan 2000

Brosius J, Konings D

Abstract excerpt

It has been suggested that the mutation at position 717 of the amyloid precursor protein (APP), found in several cases of familial Alzheimer's disease, affects the secondary structure of the corresponding messenger RNA and the rate of its translation (10). Phylogenetic analysis based on compariso...

Topics

Alzheimer Disease
Amyloid beta-Protein Precursor
Animals
Base Sequence
Humans
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
RNA, Messenger

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.