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Article

Familial Alzheimer's mutation: mRNA secondary structure revisited.

Neurobiology of aging - 1 Jan 2000

Brosius J, Konings D

Abstract excerpt

It has been suggested that the mutation at position 717 of the amyloid precursor protein (APP), found in several cases of familial Alzheimer's disease, affects the secondary structure of the corresponding messenger RNA and the rate of its translation (10). Phylogenetic analysis based on comparison with other mammalian APP sequences does not support this possibility.

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Identifiers

PMID: 1625775
DOI: 10.1016/0197-4580(92)90120-m

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Familial Alzheimer's mutation: mRNA secondary structure revisited.PMID 1625775Read ↗

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