Article
Analysis of allele fidelity, polymorphic information content, and density of microsatellites in a genome-wide screening for hip dysplasia in a crossbreed pedigree.
The Journal of heredity - 1 Jan 2005
Mateescu R G, Zhang Z, Tsai K, Phavaphutanon J, Burton-Wurster N I, Lust G, Quaas R, Murphy K, Acland G M, Todhunter R J
Abstract excerpt
Recent advances in genomics resources and tools are facilitating quantitative trait locus mapping. We developed a crossbreed pedigree for mapping quantitative trait loci for hip dysplasia in dogs by crossing dysplastic Labrador Retrievers and normal Greyhounds. We show that one advantage to using a crossbreed pedigree is the increased marker informativeness in the backcross/F2 population relative to the founder...
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