Article
The long (and winding) road to gene discovery for canine hip dysplasia.
Veterinary journal (London, England : 1997) - 1 Aug 2009
Zhu Lan, Zhang Zhiwu, Friedenberg Steven, Jung Seung-Woo, Phavaphutanon Janjira, Vernier-Singer Margaret, Corey Elizabeth, Mateescu Raluca, Dykes Nathan, Sandler Jody, Acland Gregory, Lust George, Todhunter Rory
Abstract excerpt
Hip dysplasia is a common inherited trait of dogs that results in secondary osteoarthritis. In this article the methods used to uncover the mutations contributing to this condition are reviewed, beginning with hip phenotyping. Coarse, genome-wide, microsatellite-based screens of pedigrees of greyhounds and dysplastic Labrador retrievers were used to identify linked quantitative trait loci (QTL). Fine-mapping...
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