Article
Molecular analysis of the simultaneous production of two SHV-type extended-spectrum beta-lactamases in a clinical isolate of Enterobacter cloacae by using single-nucleotide polymorphism genotyping.
Antimicrobial agents and chemotherapy - 1 Nov 2005
Szabó Dóra, Melan Melissa A, Hujer Andrea M, Bonomo Robert A, Hujer Kristine M, Bethel Christopher R, Kristóf Katalin, Paterson David L
Abstract excerpt
Bacteria that simultaneously produce multiple extended-spectrum beta-lactamases are frequently isolated. We report an Enterobacter cloacae isolate, ES24, producing four different beta-lactamases (AmpC type beta-lactamase, TEM-1, SHV-7, and a novel extended-spectrum beta-lactamase, SHV-30). Direct sequencing of bla(SHV) gene products gave a "double peak" at position 703, suggesting the presence of more than one...
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