Article
Investigation of genetic diversity of the bla(SHV) gene and development of an oligonucleotide microarray to detect mutations in the bla(SHV) gene.
Microbial drug resistance (Larchmont, N.Y.) - 1 Dec 2012
Dong Yuanyuan, Sheng Haihui, Zeng Xainting, Yan Jufen, Li Haiyan, Xiao Huasheng, Li Xiaokun, Yang Shulin
Abstract excerpt
SHV β-lactamases, including SHV extended-spectrum β-lactamases, are widespread throughout the world, and confer a broad spectrum of resistance to antibiotic drugs. Mutations ranging from single base-pair substitutions to small deletions within bla(SHV) often result in diminished activity and an increased susceptibility to β-lactamase inhibitors. Here, we collected 1,320 clinical isolates from three hospitals in...
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