Article
SHV-type extended-spectrum beta-lactamase production is associated with Reduced cefepime susceptibility in Enterobacter cloacae.
Journal of clinical microbiology - 1 Oct 2005
Szabó Dóra, Bonomo Robert A, Silveira Fernanda, Pasculle A William, Baxter Carla, Linden Peter K, Hujer Andrea M, Hujer Kristine M, Deeley Kathleen, Paterson David L
Abstract excerpt
Cefepime is a potentially useful antibiotic for treatment of infections with Enterobacter cloacae. However, in our institution the MIC(90) for E. cloacae bloodstream isolates is 16 microg/ml. PCR amplification of bla genes revealed that one-third (15/45) of E. cloacae bloodstream isolates produced SHV-type extended-spectrum beta-lactamases (ESBLs) in addition to hyperproduction of AmpC-type beta-lactamases. The...
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