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Article

Gonadal effects of a mouse Denys-Drash syndrome mutation.

Transgenic research - 1 Oct 2005

Patek C E, Saunders P T K, Miles C G, Berry R L, Hastie N D, Sharpe R M, Hooper M L

Abstract excerpt

Gonadal effects of the Denys-Drash syndrome (DDS) mutation Wt1(tmT396 )were examined in chimaeric and heterozygous mice. Since the only heterozygote was 41,XXY, Sertoli cell function was assessed by comparison with age-matched control XXY testes. Control XXY Sertoli cells showed immuno-expression of WT1 and androgen receptor (AR) indistinguishable from wild-type (40,XY), but expressed anti-Mullerian hormone...

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Source

Identifiers

PMID: 16245160
DOI: 10.1007/s11248-005-7216-y

Genes

AMH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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