Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New evidence for assessing tetrahydrobiopterin (BH(4)) responsiveness.

Metabolism: clinical and experimental - 1 Dec 2012

Bueno María A, Lage Sergio, Delgado Carmen, Andrade Fernando, Couce María L, González-Lamuño Domingo, Pérez Manuel, Aldámiz-Echevarría Luis

Abstract excerpt

OBJECTIVE: To evaluate the protocol we propose for detecting BH(4)-responsive patients and the possibility of delimiting more precisely the population to be tested. METHODS: We recruited 102 phenylketonuric patients on a phenylalanine (Phe)-restricted diet. The initial stage of the protocol was a 24-h BH(4) loading test involving Phe loading and subsequent ingestion of the cofactor, a 50% fall in blood Phe levels...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biopterins
Share to Follow-Up Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenylalanine

Share to Phenylketonurias

Share to Pilot Projects

Share to Reproducibility of Results

Share to Treatment Outcome

Source

Identifiers

PMID: 22921945
DOI: 10.1016/j.metabol.2012.07.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New evidence for assessing tetrahydrobiopterin (BH(4)) responsiveness.PMID 22921945Read ↗

Optimized loading test to evaluate responsiveness to tetrahydrobiopterin (BH4) in Brazilian patients with phenylalanine hydroxylase deficiency.Semantic proximity Read ↗

Does the 48-hour BH4 loading test miss responsive PKU patients?Semantic proximity Read ↗

Extended tetrahydrobiopterin loading test in the diagnosis of cofactor-responsive phenylketonuria: a pilot study.Semantic proximity Read ↗

Effect of BH(4) supplementation on phenylalanine tolerance.Semantic proximity Read ↗

Assessment of tetrahydrobiopterin (BH(4))-responsiveness and spontaneous phenylalanine reduction in a phenylalanine hydroxylase deficiency population.Semantic proximity Read ↗

Tetrahydrobiopterin responsiveness in patients with phenylketonuria.Semantic proximity Read ↗

Long-term follow-up of patients with phenylketonuria treated with tetrahydrobiopterin: a seven years experience.Semantic proximity Read ↗

Response of patients with phenylketonuria in the US to tetrahydrobiopterin.Semantic proximity Read ↗

Pharmacokinetics of orally administered tetrahydrobiopterin in patients with phenylalanine hydroxylase deficiency.Semantic proximity Read ↗

Tetrahydrobiopterin responsiveness in phenylketonuria: prediction with the 48-hour loading test and genotype.Semantic proximity Read ↗

Response of phenylketonuria to tetrahydrobiopterin.Semantic proximity Read ↗

The tetrahydrobiopterin loading test in 36 patients with hyperphenylalaninaemia: evaluation of response and subsequent treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.