Estrogen Receptor α–Negative Breast Cancer Tissues Express Significant Levels of Estrogen-Independent Transcription Factors, ERβ1 and ERβ5: Potential Molecular Targets for Chemoprevention

Abstract excerpt

We have investigated the expression of two estrogen receptor beta (ERbeta) isoforms, ERbeta1 and ERbeta5, which activate gene transcription independent of estrogen or growth factors, in ERalpha-negative breast cancer tissues. We report here, for the first time, that ERalpha-negative tissues express significant levels of ERbeta1 and ERbeta5, and their expression levels are not different from levels in ERalpha...

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