Article
Sleep and body temperature responses in an acute viral infection model are altered in interferon type I receptor-deficient mice.
Brain, behavior, and immunity - 1 May 2006
Traynor Tim R, Majde Jeannine A, Bohnet Stewart G, Krueger James M
Abstract excerpt
Type I interferons (IFNs) include IFNalpha and IFNbeta, both of which are elevated in acute viral infections and both of which have been shown to induce symptoms such as fever and somnolence when administered in pharmacological doses. To investigate the role of type I IFNs in mediation of acute respiratory viral symptoms we examined sleep and body temperature responses in mice with a targeted mutation of the IFN...
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