Article
Pseudomonas aeruginosa inhibits endocytic recycling of CFTR in polarized human airway epithelial cells.
American journal of physiology. Cell physiology - 1 Mar 2006
Swiatecka-Urban Agnieszka, Moreau-Marquis Sophie, Maceachran Daniel P, Connolly John P, Stanton Caitlin R, Su John R, Barnaby Roxanna, O'toole George A, Stanton Bruce A
Abstract excerpt
The most common mutation in the CFTR gene in individuals with cystic fibrosis (CF), DeltaF508, leads to the absence of CFTR Cl(-) channels in the apical plasma membrane, which in turn results in impairment of mucociliary clearance, the first line of defense against inhaled bacteria. Pseudomonas aeruginosa is particularly successful at colonizing and chronically infecting the lungs and is responsible for the...
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