Article
Non-invasive fetal RHD and RHCE genotyping from maternal plasma in alloimmunized pregnancies.
Prenatal diagnosis - 1 Dec 2005
Hromadnikova I, Vesela K, Benesova B, Nekovarova K, Duskova D, Vlk R, Spalova I, Gerychova R, Hakenova A, Rosenbaumova Z, Vlasin P, Vlachova A, Palasek V, Roznakova E, Calda P
Abstract excerpt
BACKGROUND: In this prospective study, we assessed the feasibility of fetal RH genotyping by analysis of DNA extracted from maternal plasma samples of alloimmunized pregnant women using real-time PCR and primers and probes targeted toward RHD (exon 7 and exon 10) and RHCE (intron 2 and exon 5) genes. METHODS: We analysed 23 alloimmunized pregnant women (16 anti-D, 5 anti-D + C, 2 anti-E) at risk of haemolytic...
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