Article
Labeling of cells with ferumoxides-protamine sulfate complexes does not inhibit function or differentiation capacity of hematopoietic or mesenchymal stem cells.
NMR in biomedicine - 1 Dec 2005
Arbab Ali S, Yocum Gene T, Rad Ali M, Khakoo Aarif Y, Fellowes Vicki, Read Elizabeth J, Frank Joseph A
Abstract excerpt
Two FDA-approved agents, ferumoxides (Feridex), a suspension of superparamagnetic iron oxide (SPIO) nanoparticles and protamine sulfate, a drug used to reverse heparin anticoagulation, can be complexed and used to label cells magnetically ex vivo. Labeling stem cells with ferumoxides-protamine sulfate (FePro) complexes allows for non-invasive monitoring by MRI. However, in order for stem cell trials or therapies...
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