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Article

LF 15-0195 generates synergistic tolerance by promoting formation of CD4+CD25+CTLA4+ T cells.

Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 2000

Xia Xiaoping, Zhang Xiao, Huang Xuyan, Li Mu, Zhao Lina, Tian Donghua, Zhong Robert, Min Wei-Ping

Abstract excerpt

The purpose of the present study was to investigate the influence of 15-deoxyspergualin (LF) on the phenotypes and functions of dendritic cells (DCs) and T cells and to further illustrate the mechanism of LF-inducing immunologic tolerance. DCs from mice were cultured and treated with varying doses of LF at specific time-points. Fluorescence-activated cell sorting (FACS) was used to verify the changes of...

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Share to Antigens, Differentiation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16224273
DOI: 10.1097/01.cji.0000175693.08608.a8

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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