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Article

Antithymocyte Globulin Induces a Tolerogenic Phenotype in Human Dendritic Cells.

International journal of molecular sciences - 11 Dec 2016

Roider Tobias, Katzfuß Michael, Matos Carina, Singer Katrin, Renner Kathrin, Oefner Peter J, Dettmer-Wilde Katja, Herr Wolfgang, Holler Ernst, Kreutz Marina, Peter Katrin

Abstract excerpt

Antithymocyte globulin (ATG) is used in the prevention of graft-versus-host disease during allogeneic hematopoietic stem cell transplantation. It is generally accepted that ATG mediates its immunosuppressive effect primarily via depletion of T cells. Here, we analyzed the impact of ATG-Fresenius (now Grafalon®) on human monocyte-derived dendritic cells (DC). ATG induced a semi-mature phenotype in DC with...

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Identifiers

PMID: 27973435
DOI: 10.3390/ijms17122081
PMCID: PMC5187881

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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