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Article

Isolation of monomeric human V(H)s by a phage selection.

The Journal of biological chemistry - 16 Dec 2005

To Rebecca, Hirama Tomoko, Arbabi-Ghahroudi Mehdi, MacKenzie Roger, Wang Ping, Xu Ping, Ni Feng, Tanha Jamshid

Abstract excerpt

Human V(H) domains are promising molecules in applications involving antibodies, in particular, immunotherapy because of their human origin. However, they are, in general, prone to aggregation. Therefore, various strategies have been employed to acquire monomeric human V(H)s. We had previously discovered that filamentous phages displaying engineered monomeric V(H) domains gave rise to significantly larger plaques...

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Identifiers

PMID: 16221664
DOI: 10.1074/jbc.M509900200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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