Article
Selection of rifampicin-resistant Staphylococcus aureus during tuberculosis therapy: concurrent bacterial eradication and acquisition of resistance.
The Journal of antimicrobial chemotherapy - 1 Dec 2005
Liu Youning, Cui Junchang, Wang Rui, Wang Xinjing, Drlica Karl, Zhao Xilin
Abstract excerpt
BACKGROUND AND OBJECTIVES: Acquired antimicrobial resistance is commonly attributed to regimens that expose bacteria to subinhibitory concentrations; consequently, eradication of susceptible cells is advocated. The mutant selection window hypothesis predicts that resistance can be acquired even when inhibitory concentrations are exceeded and susceptible bacteria are eradicated. The objective was to test that...
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