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Article

Sumoylation and acetylation play opposite roles in the transactivation of PLAG1 and PLAGL2.

The Journal of biological chemistry - 9 Dec 2005

Zheng Gang, Yang Yu-Chung

Abstract excerpt

PLAG1 (pleomorphic adenoma gene 1) and PLAGL2 (PLAG-like 2) are oncogenes involved in various malignancies. Thus the study of their regulatory mechanisms may lead to identification of novel therapeutic targets. In this study, we provide supporting evidence that sumoylation and acetylation regulate functions of PLAG1 and PLAGL2. A conserved transcriptional repression domain exists in both PLAG1 and PLAGL2, whose...

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Source

Identifiers

PMID: 16207715
DOI: 10.1074/jbc.M504334200

Genes

PLAG1
PLAGL2
HDAC7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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