Article
Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3.
Molecular psychiatry - 1 Feb 2006
McQuillin A, Bass N J, Kalsi G, Lawrence J, Puri V, Choudhury K, Detera-Wadleigh S D, Curtis D, Gurling H M D
Abstract excerpt
Linkage analyses of bipolar families have confirmed that there is a susceptibility locus near the telomere on chromosome 21q. To fine map this locus we carried out tests of allelic association using 30 genetic markers near the telomere at 21q22.3 in 600 bipolar research subjects and 450 ancestrally matched supernormal control subjects. We found significant allelic association with the microsatellite markers...
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