Article
[Mutations in Francisella tularensis, decreasing the virulence of these bacteria and leading to a change in the immune response upon infection of experimental animals with them].
Molekuliarnaia genetika, mikrobiologiia i virusologiia - 1 Jan 1992
Aleshkin G I, Komissarova L V, Savel'eva R A, Zakharenko V I, Loginskiĭ P Iu, Skavronskaia A G
Abstract excerpt
The research was aimed at isolation of Francisella tularensis mutants possessing the decreased virulence for experimental animals and mediating the changes in the animal immune response. A number of spontaneous and induced mutants of the American and European subtypes of Francisella tularensis were selected for antibiotics resistance or detergent sensitivity. All the obtained mutants have the decreased virulence...
Topics
- Animals
- Antibody Formation
- Blotting, Western
- Detergents
- Drug Resistance, Microbial
- Electrophoresis, Polyacrylamide Gel
- Francisella tularensis
- Genes, Bacterial
- Immune Sera
- Mutation