Article
A unique gene expression signature discriminates familial Alzheimer's disease mutation carriers from their wild-type siblings.
Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 2005
Nagasaka Yosuke, Dillner Karin, Ebise Hayao, Teramoto Reiji, Nakagawa Hiroyuki, Lilius Lena, Axelman Karin, Forsell Charlotte, Ito Akira, Winblad Bengt, Kimura Toru, Graff Caroline
Abstract excerpt
Alzheimer's disease (AD) is a neurodegenerative disease with an insidious onset and progressive course that inevitably leads to death. The current diagnostic tools do not allow for diagnosis until the disease has lead to irreversible brain damage. Genetic studies of autosomal dominant early onset familial AD has identified three causative genes: amyloid precursor protein (APP), presenilin 1 and 2 (PSEN1 and...
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