Article
[The C46359T polymorphism of DNMT3B promoter gene and pathogenesis of acute leukemia].
Zhonghua nei ke za zhi - 1 Aug 2005
Li Yuan, Dai Yue, Wu Shu-lan, Pei Pei, Cao Xiang-hong, Pu Ding-fang
Abstract excerpt
OBJECTIVE: To explore the relationship between the polymorphism of C46359T in DNMT3B promoter and the pathogenesis of acute leukemia (AL). METHODS: PCR-RFLP and DNA sequencing were used to analyze the genotypic polymorphism C46359T of promoter in genomic DNA of bone marrow cells/blood lymphocytes from 160 patients with AL and 240 normal controls. RESULTS: In people of the Hans in China, genotypic frequencies of...
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