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Article

Amplification and overexpression of CKS1B at chromosome band 1q21 is associated with reduced levels of p27 Kip1 and an aggressive clinical course in multiple myeloma

1 Sept 2005

Abstract excerpt

The molecular basis for aggressive transformation of multiple myeloma (MM) and other cancers is not completely understood. Global gene expression profiling on highly purified malignant plasma cells from 351 newly diagnosed patients with MM treated with autologous stem cell transplantation revealed a statistically significant over-representation of chromosome 1 genes in a group of 70 genes whose expression was...

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PMID: 16188652
DOI: 10.1080/10245330512331390140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Amplification and overexpression of CKS1B at chromosome band 1q21 is associated with reduced levels of p27 Kip1 and an aggressive clinical course in multiple myelomaPMID 16188652Read ↗

Gene expression profiling defines a high-risk entity of multiple myeloma.Semantic proximity Read ↗

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Prognostic significance of copy-number alterations in multiple myeloma.Semantic proximity Read ↗

Additional copies of 1q negatively impact the outcome of multiple myeloma patients and induce transcriptomic deregulation in malignant plasma cellsSemantic proximity Read ↗

A novel human multiple myeloma cell line with genetic abnormality of 1q21 gains only and CKS1B overexpressionSemantic proximity Read ↗

Outcome of Multiple Myeloma with Chromosome 1q Gain and 1p Deletion after Autologous Hematopoietic Stem Cell Transplantation: Propensity Score Matched AnalysisSemantic proximity Read ↗

BUB1B and circBUB1B_544aa aggravate multiple myeloma malignancy through evoking chromosomal instabilitySemantic proximity Read ↗

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Systematic characterization of therapeutic vulnerabilities in Multiple Myeloma with Amp1q reveals increased sensitivity to the combination of MCL1 and PI3K inhibitorsSemantic proximity Read ↗

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