Article
[Association of thymidylate synthase polymorphism with esophageal squamous-cell carcinoma].
Zhonghua zhong liu za zhi [Chinese journal of oncology] - 1 Aug 2005
Cui Ya-jing, Li Yan, Wang Rui, Guo Wei, Wang Na, Wen Deng-gui, Wei Li-zeng, Zhang Jian-hui
Abstract excerpt
OBJECTIVE: To explore the influence of 5'UTR tandem repeat and 3'UTR 6 bp deletion polymorphism of thymidylate synthase (TS) gene on the development and lymphatic metastases of esophageal squamous-cell carcinoma (ESCC). METHODS: Peripheral leucocyte DNA was extracted from 232 ESCC patients and 348 age- and sex-matched healthy controls. TS 5'UTR and 3'UTR genotyping in all study subjects was performed by PCR...
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