Article
Gene transfer of prostaglandin synthase maintains patency of the newborn lamb arterial duct.
Pediatric research - 1 Nov 2005
Humpl Tilman, Zaidi Syed H E, Coe James Y, Russell Jennifer, Kaneda Yasufumi, Massaeli Hamid, Benson Lee N, Rabinovitch Marlene
Abstract excerpt
In congenital heart disease with left- or right-sided obstruction, prostaglandin E (PGE)1 or PGE2 is infused to maintain ductus arteriosus (DA) patency. We hypothesized that transfection of the DA with PGE synthase would lead to a greater production of PGE2 in situ and, hence, patency of the DA. The cDNA for human prostaglandin synthase was sequenced and ligated into a eukaryotic expression vector. The negative...
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