Article
Lack of an adrenal cortex in Sf1 mutant mice is compatible with the generation and differentiation of chromaffin cells.
Development (Cambridge, England) - 1 Oct 2005
Gut Philipp, Huber Katrin, Lohr Jennifer, Brühl Barbara, Oberle Stephan, Treier Mathias, Ernsberger Uwe, Kalcheim Chaya, Unsicker Klaus
Abstract excerpt
The diversification of neural-crest-derived sympathoadrenal (SA) progenitor cells into sympathetic neurons and neuroendocrine adrenal chromaffin cells was thought to be largely understood. In-vitro studies with isolated SA progenitor cells had suggested that chromaffin cell differentiation depends crucially on glucocorticoids provided by adrenal cortical cells. However, analysis of mice lacking the glucocorticoid...
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