Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells.

doi:10.1242/dev.126.13.2935

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Article

Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells.

Development (Cambridge, England) - 1 Jul 1999

Finotto S, Krieglstein K, Schober A, Deimling F, Lindner K, Brühl B, Beier K, Metz J, Garcia-Arraras J E, Roig-Lopez J L, Monaghan P, Schmid W, Cole T J, Kellendonk C, Tronche F, Schütz G, Unsicker K

Abstract excerpt

Molecular mechanisms underlying the generation of distinct cell phenotypes is a key issue in developmental biology. A major paradigm of determination of neural cell fate concerns the development of sympathetic neurones and neuroendocrine chromaffin cells from a common sympathoadrenal (SA) progenitor cell. Two decades of in vitro experiments have suggested an essential role of glucocorticoid receptor (GR)-mediated...

Topics

Adrenal Glands
Animals
Apoptosis
Biomarkers
Catecholamines
Chromaffin Cells
Chromogranins
Gene Expression Regulation, Developmental
Gene Targeting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homeodomain Proteins

Immunohistochemistry

In Situ Nick-End Labeling

Mice

Mice, Knockout

Microscopy, Electron

Mutation

Nerve Tissue Proteins

Neurons

Source

Open in PubMed

Identifiers

PMID: 10357937
DOI: 10.1242/dev.126.13.2935

Genes

GAP43
PNMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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