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Article

BRCA1 in hormonal carcinogenesis: basic and clinical research.

Endocrine-related cancer - 1 Sept 2005

Rosen E M, Fan S, Isaacs C

Abstract excerpt

The breast and ovarian cancer susceptibility gene-1 (BRCA1) located on chromosome 17q21 encodes a tumor suppressor gene that functions, in part, as a caretaker gene in preserving chromosomal stability. The observation that most BRCA1 mutant breast cancers are hormone receptor negative has led some to question whether hormonal factors contribute to the etiology of BRCA1-mutant breast cancers. Nevertheless, the...

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Source

Identifiers

PMID: 16172191
DOI: 10.1677/erc.1.00972

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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BRCA1 in hormonal carcinogenesis: basic and clinical research.PMID 16172191Read ↗

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