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Article

Structure and function of the human Gly1619Arg polymorphism of M6P/IGF2R domain 11 implicated in IGF2 dependent growth.

Journal of molecular endocrinology - 1 Apr 2009

Rezgui Dellel, Williams Christopher, Savage Sharon A, Prince Stuart N, Zaccheo Oliver J, Jones E Yvonne, Crump Matthew P, Hassan A Bassim

Abstract excerpt

The mannose 6-phosphate/IGF 2 receptor (IGF2R) is comprised of 15 extra-cellular domains that bind IGF2 and mannose 6-phosphate ligands. IGF2R transports ligands from the Golgi to the pre-lysosomal compartment and thereafter to and from the cell surface. IGF2R regulates growth, placental development, tumour suppression and signalling. The ligand IGF2 is implicated in the growth phenotype, where IGF2R normally...

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Cell Membrane
Flow Cytometry
Half-Life
Insulin-Like Growth Factor II
Ligands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Transport

Receptor, IGF Type 2

Surface Plasmon Resonance

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Open in PubMed Open full text

Identifiers

PMID: 19208780
DOI: 10.1677/JME-08-0154
PMCID: PMC2659294

Genes

IGF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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