Article
Association of IGF-1 Levels With Height From Childhood to Adulthood: An Observational and Mendelian Randomization Study.
The Journal of clinical endocrinology and metabolism - 20 Feb 2026
De La Barrera Benjamin, De La Barrera Samuel, Gamache Isabel, Harnois-Leblanc Soren, Fagbemi Kaossarath, Ong Ken K, Manousaki Despoina
Abstract excerpt
CONTEXT: Growth hormone therapy, which increases circulating levels of insulin-like growth factor 1 (IGF-1), effectively enhances adult height in children with idiopathic short stature, although with varying responses. OBJECTIVE: To explore the question whether normal IGF-1 variation within a population is causally associated with height across childhood and in adulthood. METHODS: We used two-sample Mendelian...
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