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Article

Abnormal folate metabolism in mothers with Down syndrome offspring: review of the literature.

European journal of obstetrics, gynecology, and reproductive biology - 1 Feb 2006

Eskes T K A B

Abstract excerpt

Altered maternal folate status and homozygous mutation in the methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes can promote chromosomal instability and non-dysjunction resulting in fetal trisomy 21. Folate supplementation around conception therefore has the potential to reduce the frequency of Down syndrome. This finding, in addition to the prevention of neural tube...

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16169148
DOI: 10.1016/j.ejogrb.2005.07.028

Genes

MTHFR
MTRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Abnormal folate metabolism in mothers with Down syndrome offspring: review of the literature.PMID 16169148Read ↗

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